International Research Journal of Gastroenterology and Hepatology

Updated: Dec 1, 2021

A Liver Manifestation; Hepatic Cirrhosis and its

Management through Electrohomoeopathy: An

Overview: Dr. Ajit Singh

International Research Journal of Gastroenterology and Hepatology 4(2): 9-19, 2021; Article no.IRJGH.69453 A Liver Manifestation; Hepatic Cirrhosis and its Management through Electro-Homoeopathy: An Overview Ajit Singh1* and Sanjay Mishra2 1Department of Electrohomoeopathy Pharmacy, Kings Herbal Research Laboratories, Jalandhar- 144023 , Punjab- India. 2Regional Food Research and Analysis Centre (RFRAC), Udyan Bhavan Campus, 2, Sapru Marg, Lucknow- 226001, U.P., India. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information Editor(s): (1) Dr. Syed Faisal Haider, King Saud Bin Abdulaziz University for Health, Kingdom of Saudi Arabia. Original Research Article ABSTRACT Reviewers: (1) Denise Herzog, Switzerland. (2) Byron Leonel Saraguro Ramirez, Universidad Central del Ecuador, Ecuador. (3) MICHEAL VINCENT ABIODUN, Federal Polytechnic Bida, Nigeria. Complete Peer review History: Received 10 April 2021 Accepted 15 June 2021 Published 16 June 2021 Hepatic Cirrhosis is recognized by the formation of regenerative nodules in liver parenchyma bounded by fibrous septa consequent to chronic liver injury. Cirrhosis occurs because of necrosis of liver cells followed by fibrosis and nodule formation. The liver organization becomes abnormal and interferes with liver blood flow and function, and ultimately leads to portal hypertension and hepatocytic dysfunction. Chronic liver diseases represent a noteworthy health problem across the globe with liver cirrhosis. The exact prevalence of cirrhosis worldwide was obscure due to the clinical continuum ranging from indolent, asymptomatic to complete liver decompensation. Thus, continual inputs through a series of research considering various conventional and certain earlier techniques in background, along this thrust medical area, led an emerging and medically most precise an alternate technique, namely, Electro-Homoeopathic Medical Science that has been currently in practice by several practitioners in India revealing fascinating outcome without any _____________________________________________________________________________________________________ *Corresponding author: E-mail:;

Singh and Mishra; IRJGH, 4(2): 9-19, 2021; Article no.IRJGH.69453 significant post therapeutic physiological and/or biochemical side effect as well as risk factor. The efficacy of electrohomeopathy treatment for liver disease was successfully evaluated over a 60-day period based on improved subjective parameters and hematological investigations. The result of this survey provides new information on the development and establishment of an increasingly advanced version of the electro-homeopathic system for a precise diagnosis revealing a specific root cause and smooth-running management of Liver Disease as well as its manifestation. Keywords: Clinical continuum; electro-homeopathy; fibrosis; liver cirrhosis; hepatocytic dysfunction; liver manifestations. 1. INTRODUCTION 1. INTRODUCTION Modern science explains ,Liver fibrosis is dynamic change in normal wound healing response to different fibrogenic stimuli leading to activation and trans differentiation of liver stellate cells to myofibroblasts that leads to excessive synthesis and deposition of extracellular matrix components like collagen (type I and type III) accompanied by deformation of normal hepatic vasculature, hepatocyte dysfunction, irreversible liver injury, complications, and result in mortality [1]. Cirrhosis represents the common pathway for chronic liver diseases [2-10]. The progression of liver injury to cirrhosis may take place over weeks to years. Patients with hepatitis C may have chronic hepatitis for as long as 40 years before progressing to cirrhosis. Various types of hepatic injury are marked by fibrosis, defined as an overload deposition of the components of the extracellular matrix (collagens, glycoproteins, and proteoglycans) within the liver. Besides fibrosis, the complications of cirrhosis consist of portal hypertension, ascites, hepatorenal syndrome and hepatic encephalopathy. A few patients with cirrhosis are asymptomatic and have a rationally normal life expectancy while some individuals have severe symptoms of end- stage liver disease and narrow chance for survival, (when the cause is not diagnosed in proper time.) According to the concept of electrohomeopathy, liver cirrhosis is the result of a "vitiation" which can occur either because of blood, lymph or both. It had been noticed that a person belongs to the Sanguine and Mixed constitution are more prone in comparison to persons of lymphatic constitution [11-12]. General signs and symptoms may come up from decreased liver synthetic function (coagulopathy), reduced detoxification capabilities of the liver (hepatic encephalopathy) or portal hypertension (variceal bleeding) [13-15]. The present overview is the assemblage of overall studies aiming at pathophysiology, symptoms and diagnosis of ‘Liver Cirrhosis’ as well as its management through Electro-Homeopahy under following major heads: 2. ELECTROHOMOEOPATHY PATHOP- HYSIOLOGY Electrohomoeopathy describes that Disease is the result of a Vitiation in the body so, in the absence of Vitiation, the liver plays a vital role in the synthesis of proteins such as albumin, clotting factors, harmonizing factors and detoxification and storage of vitamin A. It is involved in the metabolism of lipids and carbohydrates. Once the vitiation occurred and not managed in time, it leads to hepatitis and steatosis and later in the stage, cirrhosis. Vitiation is also a cause and provides a medium for many microorganisms to develop and reproduce in tissues that contribute more to the propagation of infection [16]. Histopathologic results revealed, in cirrhosis a development of scar tissue replaces normal parenchyma and checks portal blood flow to the organ and affects normal function. Research in modern science reveals the imperative role of the stellate cell in the development of cirrhosis that generally stores vitamin A [17]. Hepatic parenchyma injuries due to the inflammation activate stellate cell, ultimately increases fibrosis followed by obstruction of the blood circulation. The formation of fibrous tissue bands separate hepatocyte nodules, which replace the entire liver architecture [18,17], leading to decreased blood flow throughout (Fig. 1).The spleen becomes congested, and enlarged resulting in its retention of platelets, which are needed for normal blood clotting. Portal hypertension is responsible for the most severe complications of cirrhosis. In addition, stellate cells secrete TGF beta 1 that leads to a fibrotic response and proliferation 10

of connective tissue. Moreover, it secretes TIMP1 and TIMP2, naturally occurring inhibitors of matrix metalloproteinases, which prevent them from breaking down the fibrotic material in the extracellular matrix. The pathologic features of cirrhosis includes regenerating nodules separated by fibrous septa and loss of the normal lobular architecture within the nodules which leads to decreased blood flow throughout the liver. Spleen congestion leads to hypersplenism and increased sequestration of platelets [19]. Two types of cirrhosis have been described based on the underlying cause (a) Micro nodular cirrhosis in which regenerating nodules size is about less than 3 mm and the involvement of entire liver and often caused by alcohol induced damage or biliary tract disease. (b) Macro nodular cirrhosis in which the variable size nodules are formed and normal acini is seen within the larger nodules and it is often associated with chronic viral hepatitis. 3. SYMPTOMS AND COMPLICATIONS OF CIRRHOSIS In early stage of cirrhosis there are generally no symptoms. As the Vitiation Progressive, condition causes symptoms like:- Soreness: in the abdomen. Gastrointestinal: bleeding, dark stools from digested blood, fluid in the abdomen, nausea, passing excessive quantities of gas, vomiting of blood, or water retention. Whole body: tiredness, loss of appetite or decreased hormone production. Skin: a web of blood vessels swollen into the skin or yellow skin and eyes. Weight: Gain or lose weight. Also common: bleeding, breast augmentation, bruising, dark urine, itching, mental confusion, muscle weakness, shortness of breath, swelling of extremities, or swollen veins in the lower oesophagus. and various complications are as (a) Impaired metabolic and endocrine functions (b) Splenomegaly due to portal hypertension; (c) Haematologicalderangements such as thrombocytopenia; (d) Gastrointestinal varices; (e) Ascites a severe complication due to portal hypertension; (f) Spontaneous bacterial peritonitis; (g) Hepatocelluar carcinoma; (h) Hepatic encephalopathy; (i) Hyponatremia; (j) Hepatorenal syndrome; (k) Spider angiomata due to decreased oestradiol degradation in liver [20]. 4. ELECTROHOMOEOPATHY DIAGNO- SIS Having past experiences research studies on various conventional and certain earlier diagnostic tools, the diagnosis was accomplished as per the concept of “Electrohomoeopathy”, in which it is ascertained on priority that the patient belongs to which type of Vitiation. (Blood, Lymph or Both) [13] [20-23]. It was found mostly the patients suffering with Liver organ disorders and its manifestations belong to the ‘Vitiation’ of Blood or both and patients suffered with ‘Vitiation’ of Lymph were low in number with liver problems and its manifestation as compared to “Vitiation of Blood” [24-25]. Therefore, understanding the type of “Vitiation” was the first step of diagnosis in electro-homeopathy which is confirmed on the basis of the patient's constitution. After this, attention is brought to notice the symptoms of the problem and makes the other clinical examinations according to the clinical diagnostic methodology. The symptoms gave an indication of the involvement of the organ system that was sick due to the impact of the diagnosed “Vitiation”. This effect of vitiation was verified by studying the patient's iris analysis as shown below for liver manifestations To verify the impact of Vitiation on Liver, Electrohomoeopathy centers [Table-2] could often take help from the modern diagnostic tools as below:- (a) Serological: Aspartate aminotransferase (AST), Alanine transaminase (ALT), Alkaline phosphatase (ALP), bilirubin, prothrombin time, Gamma-glutamyl transpeptidase, albumin, immunoglobulins principally IgG, creatinine level, sodium level, Low sodium reflect severe liver disease as a consequence of excessive diuretic therapy or malfunctioning free water clearance. Albumin level is reduced below 28 g/l, serum creatinine concentration increased above 130 μmol/l and the prothrombin time is extended. (b) Histological: Liver biopsy is measured as gold standard for diagnosis and sequential histological grading of fibrosis and to corroborate the type and severity of hepatic disease. Stains are required for copper and iron analysist to verify diagnosis of Wilson’s disease or iron overload and immunocytochemical stains detect viruses, bile ducts and angiogenic conformation. Singh and Mishra; IRJGH, 4(2): 9-19, 2021; Article no.IRJGH.69453 11

(c) Radiological Techniques (i) Ultrasonography: To identify changes in size, shape of the liver and hepatocellular carcinoma. Fatty change and fibrosis produce towering level of echogenicity. In cirrhosis, there may be deformation of the arterial vascular architecture and marginal nodularity of the liver surface. The patency of the portal and hepatic veins are assessed. Elastography is used for diagnosis and follow up observing to avoid liver biopsy. (ii) Computerized Tomography Scan (CT Scan): Arterial phase contrast enhanced scans are important in the detection of hepatocellular carcinoma. This technique reveals the picture of hepatosplenomegaly and collateral vessels enlargement below the anterior abdominal wall due to portal hypertension and dilated collaterals in liver disease. (iii) Endoscopy: For detection and treatment of portal hypertensive gastropathy and varices. (iv) Magnetic Resonance Imaging (MRI) Scan: For diagnosis of benign tumours (haemangiomas). Magnetic resonance angiography picturizes the vascular anatomy and Magnetic resonance cholangiography reveals the biliary tree. 5. ELECTROHOMOEOPATHY MANAGEMENT ALTERNATE TO MODERN MEDICINE MANAGEMENT OF LIVER CIRRHOSIS There have been certain ways of managing Liver Cirrhosis in modern science : (i) Nutrition and Exercise: Debilitated patients have been reported to get benefit from balanced nutrition concomitant with formal exercise program supervised by a physician [26-28]; (ii) Vaccination: Patients with chronic liver disease have been shown to receive vaccination to protect against hepatitis A and as a protective measure, vaccination against influenza and pneumococci; (iii) Analgesics: The use of analgesics in patients with cirrhosis can be problematic. Most hepatologists permits the use of acetaminophen doses of up to 2000 mg/day in patients with cirrhosis. NSAID use in patients with cirrhosis may cause gastrointestinal bleeding. Patients with cirrhosis are at risk for NSAID induced renal insufficiency because of prostaglandin inhibition and impairment in renal blood flow; (iv) Drug hepatotoxicity in the patient with Cirrhosis: Medications associated with drug- induced liver disease include NSAIDs, Isoniazid, Valproic acid, Erythromycin, Amoxicillin/ clavulanate Ketoconazole, Chlorpromazine and Ezetimibe. Statins are frequently associated with mild elevations of alanine aminotransferase level and should be used safely in patients with chronic liver disease. Besides, an amino glycoside antibiotic has been reported to cause nephrotoxicity in patients with cirrhosis and should be avoided. Low dose estrogens and progesterone appear to be safe in the setting of liver disease [13]; (v) Liver transplantation: Liver transplantation has emerged as an important strategy in the allopathic surgical management of patients with cirrhosis [13], providing rather better results as compared to previous four therapies, although with a hope of establishing most sensitive, précised and without any significant side effect (physiological and biochemical), currently electro-homeopathic therapy for management of ‘Liver Disease’ has been in popular practice. The brief account of this vital system is ascribed as follows: Singh and Mishra; IRJGH, 4(2): 9-19, 2021; Article no.IRJGH.69453 Fig. 1. Pathogenesis of fibrosis [Source: Ref. [19]Activation of the stellate cell is followed by proliferation of fibroblasts and the deposition of collagen. 12

Singh and Mishra; IRJGH, 4(2): 9-19, 2021; Article no.IRJGH.69453 (A) ( Source :Ref. [16,29] (B) ( Source :Ref. [16,29] (C) ( Source :Ref. [16,29] (D) ( Source :Ref. [16,29] (E) ( Source :Ref. [16,29] Fig. A. Sodium ring indicating Metabolic Liver dysfunction with Multiple Hormone deficiency or Imbalance Fig. B. Brown pigment with circulatory ring Indicating Liver manifestation and venous return of the blood is hampered Fig. C. Scurf ring indicating skin conditions Fig. D. Melanin Liver Pigment Fig. E. The lacuna relates to the gall bladder located at 40’ in the right eye and is small 5.1 Electro-homoeopathic Management of Liver Disease and its Manifestations Methodology: To treat the impact of Vitiation on Liver following slightly modified line of Electro- homoeopathy treatment [30-31] was adopted as:

  1. (i) A constitutional remedy prescribed to deal with the kind of Vitiation involved.

  2. (ii) A liver remedy prescribed to recover from disturbed functional and structural changes.

  3. (iii) An external application used in the form of compresses and ointments to enhance the synergistic effect of the given formulations as per the Polarity of Body (Figure F)

Overall, the clinical treatment prescribed at the 15 electrohomeopathy health centers [Table 2] for diseased liver followed the following pattern [Table-1] to treat the patients belong to different Constitution and types of Vitiations: Further, the dose was prescribed as per following rules of Law of Dosology laid down by the Count Ceasre Mattei ,Inventor of Electrohomoeopathy [27,28,30]:

  1. (i) Dose must be inversely proportional to the Gravity of a disease “which means, if the roots of disease (Vitiation) and it manifestations are chronic than dose must be given in least amount by making the lighter dilution of the prescribed medicine and Vice versa;

  2. (ii) More the remedy is diluted more frequently it must be repeated i.e. “a litre dilutions must be repeated frequently in compare to the higher dilutions.

This Concept of Electrohomoeopathy medicine dosology assisted in providing miraculous results while treating the chronic liver disease and its acute manifestations like jaundice, disturbed 13

LFT, portal hypertension, esophageal varices, gall bladder Colic, itchy skin, ascites etc. 6. RESULTS AND DISCUSSION There was a significant improvement in the health of the patients and his sufferings (Highlight data in the table). It was observed many patients belonging to this disease to fall in the age group of 35 to 65 and was mostly men as compared to women (Table 2) belong to three different types of constitution and types of Vitiation. (Table 1). The efficacy of the Electro-homoeopathy treatment for Liver Disease was evaluated in the Electrhomoeopathy Health centers over a period of 60 days based on improvement in the subjective parameters and blood investigations of modern diagnostic tool [11] [31-33]. The cytokine level in most of the patient starts to normalize within the 30 to 40 days of treatment that result also in balancing the protein loss and thus reducing the body oedema. Liver enzymes get balanced too except the Alkaline Phosphatase (ALP), which takes more time to come back into normal range. Never-the-less, level of Lactate Dehydrogenase (LDH) should also be considered as one of the potential marker enzymes signifying the biochemistry of liver in view of justifying the affinity and efficacy of the Electro-homoeopathy treatment for Liver Disease. While analyzing the patients, the maximum benefit was observed in the following complaints: Loss of appetite, restlessness, itching and balancing of Liver Enzymes and Cytokine level, concluded to be in the range, 70-80%, reflecting resemblance to the outcome of the study on immediate recent studies [30-31] in terms of affinity and efficacy of Electro- homeopathic management of Liver Cirrhosis. Singh and Mishra; IRJGH, 4(2): 9-19, 2021; Article no.IRJGH.69453 acute toxicity and hepatoprotective activity against CCl4 induced toxicity of scrofoloso 5 (S5) and livome electrohomoeopathic herbal preparations [2] Fig. 3 (F); Diagram to illustrate polarity of the body Source: Ref. [12] 14

Table 1. (Prescription of Electrohomoeopathy treatment for Liver and Its Manifestations) Singh and Mishra; IRJGH, 4(2): 9-19, 2021; Article no.IRJGH.69453 Constitutional/Vitiation Remedies for patients Vitiated Organ and its Manifestation Remedies External applications for instant relief and to support the Basic treatment in the form of compress. (As per Figure- 2) Point Body Area (Fig-2) No. 24 Hypochondria Left (Spleen) Right (Liver) 23 Kidneys (Rt and Lt) 44 Pneumogastric Nerve 27 Heart 30 Dorsal spinal Nerves Lymphatic Const. Sanguine Const. Mixed Const. S1 S2/A2 S1/A2/C1 Liver and Gall Bladder Portal hypertension Melena/constipation Ascites Thrombocytopenia Fever Followed by Chills S9 A2 /BE A2+C5+GE Slass Laxative S6/C6 A3+S1+F1 L1+S10 Remedy C5/F2 RE YE RE/BE RE/YE Table 2. Electrohomeopathic clinical survey of fifteen EH Clinics of India Practicing on Liver Cirrhosis patients (Men and Women) Involving three types vitiation in patients S.No. EH Clinic Address

  1. Rezru Electrohomoeopathy Health Centre, Jammu, Vill- Khandwal ,Near Govt Middle School

  2. Puja Clinic Bano Recedenc Kedari Nager galli no 8 near Oxford Comfort, Wanwdi, Pune – 411040, Maharshtra

  3. Shri Gajanan Electrohomoepathy Clinic,

EH Physician’s Name Dr.Suresh Kumar Mob-9419608951 Dr Shilpa Patil Mob-9168915294 Number of Patients Attended (2015- 2020) 20 20 (Cirrhosis of Liver) 30 (Liver Disease and its manifestation) Patients’ Age Groups Constitution Types Of patients Type of Vitiation in Patients Dr. Virendra Girase 40 (Liver Disease 35-50 and its manifestation) 15 No. 25 Types Sanguine 40-65 40-60 No. 15 03 02 No. 28 02 Types Sanguine Mixed Lymphatic Types Sanguine Mixed No. 15 03 02 No. 28 02 No. 25 Types Blood Blood and Lymph Lymph Types Blood Blood and Lymph Types Blood

Singh and Mishra; IRJGH, 4(2): 9-19, 2021; Article no.IRJGH.69453 S.No. EH Clinic Address Nakane Road, Dhule- 424002, Maharashtra

  1. Ayush clinic Main road Bhiwapur Dist Nagpur (Maharashtra) 441201

  2. Mahi Chiktasalaya , Ist Floor, Prathma UP Grameen Bank, Near Shabir Ground, Badaun - 243601 Uttar Pradesh

  3. Sahara clinic Somavar peth,chikodi (Karnataka) 591201

  4. EH Herbal Clinic Girish Market Birla Coloney patna (Bihar ) 801505

  5. Gurudeo EH Research Centre, A/P-Khambada Tal-Chimur Dist. Chandrpur (Maharashtra ) 442904

  6. Sanjeevani EH Chikitsalaya Camp Road Malegaon dist Nasik (Maharashtra ) 423202

  7. Shir EH Research centre

EH Physician’s Name Mob-9922119220 Dr. K.B Kakde Mob- 9545499488 Dr. Sanjeev Kumar Shakya Mob- 9458844925 Dr. Nisarhmed Ammangi Mob- 9448420368 Dr. Amar Kant Kumar Mob- 8179654917 Dr. Gopichand Gajbhe Mob- 9403300509 Dr. Shivdas Pagar Mob-9881991150 Dr. Amit Pati Number of Patients Attended 2020) (2015- Type of Vitiation in Patients Blood and Lymph Types Blood Blood and Lymph Types Blood Blood and Lymph Types Blood Blood and Lymph Lymph Types Blood Types Blood Blood and Lymph Types Blood Blood and Lymph Types Patients’ Age Groups 15 40-60 No. 25 05 No. 30 50-65 20 30-60 No 30 10 05 45-55 No, 15 50-60 No. 20 05 45-55 No. 09 01 50-55 No. Constitution Types Of patients Mixed Types No. Sanguine 25 Mixed 05 Types No. Sanguine 30 Mixed 20 Types No. Sanguine 30 Mixed Lymphatic Types No. Sanguine 15 Types No. Sanguine 20 Mixed 05 Types No. Sanguine 09 Mixed 01 Types No. 30 (Liver Disease and its manifestation) 50 ( Liver Disease and its complication) 45 cases of Liver and its manifestation 15 cases of Liver and its manifestation 25 cases of Liver and its manifestation 10 cases of Liver and its manifestation 15 cases of Liver 16

Singh and Mishra; IRJGH, 4(2): 9-19, 2021; Article no.IRJGH.69453 S.No. EH Clinic Address Loog Jani Galli Kupwad Dist- sangli (Maharashtra) 416436

  1. Chander Nature E/H Clinic. Sarna Nehar Pathankot Punjab-145025

  2. Gayatri Electrohomoeopathic and Iris diagnostic centre Chakrota road , Behat ,U.P

  3. Siwan advance Electro homoeopathic health care centre, Adress- Bendusar buzurg, Badharia Road, Siwan ( Bihar) 841227

  4. Advance Electrohomoeopathy health care center, Gorakhpur road nikat purani lohiawa pul kasia kushinagar (u.p)

  5. Electro homeopathic clinic In front of allahabad bank Shiwala mahant Mirzapur -Up -231001

EH Physician’s Name Mob- 9822878901 Dr Lalit Chander Mob- 92179 69139 Dr Kalyan Saini Mob-9917978434 Dr. Kanhaiya sharma Dr Raghavendra Singh Mob-97950 21159 DR. MOHD ASLAM Mob-70075 28560 Number of Patients Attended (2015- 2020) and its manifestation 20 cases of Liver and its manifestation 10 cases of Liver and its manifestation 20 cases of Liver and its manifestation 50 cases of Liver and its manifestation 20 cases of Liver and its manifestation 17 Patients’ Constitution Types Of Age Groups patients Type of Vitiation in Patients 13 Sanguine 13 Blood 02 Mixed 02 Blood and Lymph 40-60 No. Types No. Types 10 Sanguine 10 Blood 10 Mixed 10 Blood and Lymph 50-60 No. Types No. Types 04 Sanguine 04 Blood 06 Mixed 06 Blood and Lymph No. Types No. Types 15 Sanguine 15 Blood 04 Mixed 04 Blood and 25-60 Lymph 01 Lymphatic 01 Lymph 40-60 No. Types No. Types 30 Sanguine 30 Blood 17 Mixed 17 Blood and Lymph 03 Lymph 03 Lymph 30-50 No. Types No. Types 15 Sanguine 15 Blood 05 Mixed 05 Blood and Lymph

7. CONCLUSION Hepatic Cirrhosis represents the common histologic pathway for a diversity of chronic liver diseases. The injury to hepatocytes causes liver dysfunctions. In view of progression of affinity and sensitivity of therapeutic practice applying Electro-homeopathic technique has been shown to reveal fascinating outcome in terms of comparatively fast, sensitive , precise and safe medical technique without any noticeable post therapeutic physiological and/or biochemical side effects. Besides, critical comments/suggestions from relevant readers would be useful in further upgrading of Electro-homeopathic management of Liver Cirrhosis.

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